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kefF regulator of KefC-mediated potassium transport and quinone oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944767, updated on 3-Dec-2024

Summary

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Official Symbol
kefF
Official Full Name
regulator of KefC-mediated potassium transport and quinone oxidoreductase
Primary source
ECOCYC:EG11568
Locus tag
b0046
See related
ASAP:ABE-0000159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0047; yabF
Summary
Based on sequence similarity, YabF is predicted to be an NAD(P)H dehydrogenase . [More information is available at EcoCyc: EG11568].
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Genomic context

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Sequence:
NC_000913.3 (47246..47776)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase FixC Neighboring gene putative ferredoxin FixX Neighboring gene putative transporter YaaU Neighboring gene K(+) : H(+) antiporter KefC Neighboring gene dihydrofolate reductase Neighboring gene diadenosine tetraphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity. Lyngberg L, et al. J Bacteriol, 2011 Sep. PMID 21742892, Free PMC Article
  2. Construction and screening of metagenomic libraries derived from enrichment cultures: generation of a gene bank for genes conferring alcohol oxidoreductase activity on Escherichia coli. Knietsch A, et al. Appl Environ Microbiol, 2003 Mar. PMID 12620823, Free PMC Article
  3. KTN (RCK) domains regulate K+ channels and transporters by controlling the dimer-hinge conformation. Roosild TP, et al. Structure, 2009 Jun 10. PMID 19523906, Free PMC Article
  4. Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation. Miller S, et al. J Biol Chem, 1997 Oct 3. PMID 9312097
  5. The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli. Munro AW, et al. Mol Microbiol, 1991 Mar. PMID 2046548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)H dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular pH elevation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of potassium:proton antiporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
regulator of KefC-mediated potassium transport and quinone oxidoreductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    47246..47776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414588.1 regulator of KefC-mediated potassium transport and quinone oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414588.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6VS29
    Conserved Domains (1) summary
    PRK00871
    Location:1 → 176
    PRK00871; glutathione-regulated potassium-efflux system oxidoreductase KefF
Nucleotide Protein
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