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wecB UDP-N-acetylglucosamine 2-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944789, updated on 3-Dec-2024

Summary

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Official Symbol
wecB
Official Full Name
UDP-N-acetylglucosamine 2-epimerase
Primary source
ECOCYC:EG11451
Locus tag
b3786
See related
ASAP:ABE-0012372
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3778; mnaA; nfrC; rffE; yifF
Summary
Isolation of spontaneous N4 bacteriophage-resistant mutants of Escherichia coli K-12 strain SC1100, cloning of the affected genes, and subsequent complementation experiments revealed that nfrC is important in N4 adsorption . [More information is available at EcoCyc: EG11451].
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Genomic context

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Sequence:
NC_000913.3 (3970133..3971263)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene enterobacterial common antigen polysaccharide co-polymerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase Neighboring gene dTDP-glucose 4,6-dehydratase 2 Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene RffC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Active site mutants of the "non-hydrolyzing" UDP-N-acetylglucosamine 2-epimerase from Escherichia coli. Samuel J, et al. Biochim Biophys Acta, 2004 Jul 1. PMID 15210128
  2. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Campbell RE, et al. Biochemistry, 2000 Dec 12. PMID 11106477
  3. Characterization of the dTDP-rhamnose biosynthetic genes encoded in the rfb locus of Shigella flexneri. Macpherson DF, et al. Mol Microbiol, 1994 Jan. PMID 8170390
  4. Enzymatic synthesis of uridine diphosphate N-acetyl-D-mannosaminuronic acid. Kawamura T, et al. J Biol Chem, 1979 Sep 10. PMID 381306
  5. Toxicity-based selection of Escherichia coli mutants for functional recombinant protein production: application to an antibody fragment. Belin P, et al. Protein Eng Des Sel, 2004 May. PMID 15252207

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine 2-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in enterobacterial common antigen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-N-acetylglucosamine 2-epimerase
YP_026253.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3970133..3971263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026253.1 UDP-N-acetylglucosamine 2-epimerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026253.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R0G5
    Conserved Domains (1) summary
    TIGR00236
    Location:1 → 373
    wecB; UDP-N-acetylglucosamine 2-epimerase
Nucleotide Protein
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