U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ftsL cell division protein FtsL [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944803, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ftsL
Official Full Name
cell division protein FtsL
Primary source
ECOCYC:EG11086
Locus tag
b0083
See related
ASAP:ABE-0000306
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0084; mraR; yabD
Summary
The ftsL gene is essential. [More information is available at EcoGene: EG11086]. FtsL is essential for growth and cell division; the protein is present in very small amounts of approximately 25 molecules per cell . [More information is available at EcoCyc: EG11086].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (91032..91397)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator Cra Neighboring gene DNA-binding transcriptional repressor MraZ Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene D-alanyl-D-alanine-adding enzyme

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization. Ghigo JM, et al. J Bacteriol, 2000 Jan. PMID 10613870, Free PMC Article
  2. New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division. Ishino F, et al. J Bacteriol, 1989 Oct. PMID 2676977, Free PMC Article
  3. Identification of a novel function for the FtsL cell division protein from Escherichia coli K12. Blencowe DK, et al. Biochem Biophys Res Commun, 2011 Jul 22. PMID 21708137
  4. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions. Condon SGF, et al. J Biol Chem, 2018 Feb 2. PMID 29233891, Free PMC Article
  5. Bacterial cytokinesis: From Z ring to divisome. Lutkenhaus J, et al. Cytoskeleton (Hoboken), 2012 Oct. PMID 22888013, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
  2. Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
    Title: Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
  3. The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB.
    Title: Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.
  4. the data suggest that FtsL forms an uninterrupted helix across the two regions and that the integrity of this helix is indispensable for the function of the complex. The FtsL helix is thus a candidate for acting as a potential mechanical connection to communicate conformational changes between periplasmic, membrane, and cytoplasmic regions.
    Title: The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
  5. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
    Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
  6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
    Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
  7. The authors demonstrate that the leucine zipper-like (LZ) motifs, located in the periplasmic domain of FtsL and FtsB, are required for an optimal interaction between these two essential proteins.
    Title: Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB.
  8. ftsL can confer a metal-ion sensitive phenotype and trans-membrane cysteine residues play a role in FtsL function in elevated metal-ion concentrations.
    Title: Identification of a novel function for the FtsL cell division protein from Escherichia coli K12.
  9. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
    Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
  10. FtsL is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
    Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of FtsBL complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of FtsQBL complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell division site IEA
Inferred from Electronic Annotation
more info
  
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
part_of divisome complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cell division protein FtsL

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    91032..91397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414625.1 cell division protein FtsL [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414625.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MCK7
    Conserved Domains (1) summary
    PRK10772
    Location:17 → 121
    PRK10772; cell division protein FtsL; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.