cra DNA-binding transcriptional dual regulator Cra [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: cra
Official Full Name: DNA-binding transcriptional dual regulator Cra
Primary source: ECOCYC:EG10338
Locus tag: b0080
See related: ASAP:ABE-0000299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0081; fruC; fruR; shl
Summary: FruR is a dual transcriptional regulator implicated in the regulation of a large number of operons that encode enzymes which comprise central pathways of carbon metabolism. [More information is available at EcoCyc: EG10338].
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NC_000913.3 Genomic Context describing neighboring genes

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Data show that DNA-binding transcriptional dual regulators Cra and CRP are most active on poor carbon sources.
Title: Systems assessment of transcriptional regulation on central carbon metabolism by Cra and CRP.
Authors show that Cra regulates growth by activating expression of the crp gene.
Title: Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli.
The deletion of cra and kdpE resulted in the ablation of attaching and effacing lesions.
Title: Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli.
Curli biosynthesis is regulated by Cra. Cra mutants are inpaired in iofilm formation.
Title: Biofilm formation in Escherichia coli cra mutants is impaired due to down-regulation of curli biosynthesis.
Two lines of evidence indicate that a total of as many as 178 promoters are under the control of Cra.
Title: Novel members of the Cra regulon involved in carbon metabolism in Escherichia coli.
The glucose uptake rate and the acetate production rate were increased with less acetate consumption for the cra mutant.
Title: Effect of cra gene knockout together with edd and iclR genes knockout on the metabolism in Escherichia coli.
Identified as new member of the polyamine modulon together with RpoN and H-NS.
Title: Enhancement of the synthesis of RpoN, Cra, and H-NS by polyamines at the level of translation in Escherichia coli cultured with glucose and glutamate.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fructose	IEA Inferred from Electronic Annotation more info

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