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wzzE enterobacterial common antigen polysaccharide co-polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944815, updated on 17-Dec-2024

Summary

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Official Symbol
wzzE
Official Full Name
enterobacterial common antigen polysaccharide co-polymerase
Primary source
ECOCYC:EG11295
Locus tag
b3785
See related
ASAP:ABE-0012370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3777; wzz; yifC
Summary
Mutants have elevated OM vesiculation (McBroom, 2006). [More information is available at EcoGene: EG11295]. WzzE is responsible for regulating the length of phosphoglyceride-linked Enterobacterial Common Antigen (ECAPG) polysaccharide chains formed from polymerization by WzyE utilizing Lipid III in the periplasm. [More information is available at EcoCyc: EG11295].
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Genomic context

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Sequence:
NC_000913.3 (3969031..3970077)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription termination factor Rho Neighboring gene UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase Neighboring gene dTDP-glucose 4,6-dehydratase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of predicted coiled-coil regions in the Escherichia coli K-12 O-antigen polysaccharide chain length determinant Wzz. Marolda CL, et al. J Bacteriol, 2008 Mar. PMID 18203821, Free PMC Article
  2. [wzzE does not affect lipopolysaccharide phenotype of avian pathogenic Escherichia coli from clinical ducking]. Zuo J, et al. Wei Sheng Wu Xue Bao, 2016 May 4. PMID 29727150
  3. Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Kalynych S, et al. Protein Sci, 2015 Jan. PMID 25307743, Free PMC Article
  4. Sequence-structure relationships in polysaccharide co-polymerase (PCP) proteins. Morona R, et al. Trends Biochem Sci, 2009 Feb. PMID 19058968
  5. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length. Tocilj A, et al. Nat Struct Mol Biol, 2008 Feb. PMID 18204465

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WzzE is not involved in the synthesis of lipopolysaccharide but participates in the pathogenic process.
    Title: [wzzE does not affect lipopolysaccharide phenotype of avian pathogenic Escherichia coli from clinical ducking].
  2. E.coli WzzB and WzzE Polysaccharide Copolymerases form octameric homo-oligomeric complexes.
    Title: Quaternary structure of WzzB and WzzE polysaccharide copolymerases.
  3. Results suggest that the regions predicted to be coiled coils are important for Wzz function because they maintain the native conformation of the protein, although the existence of coiled coils could not be demonstrated experimentally.
    Title: Functional analysis of predicted coiled-coil regions in the Escherichia coli K-12 O-antigen polysaccharide chain length determinant Wzz.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enterobacterial common antigen polysaccharide co-polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3969031..3970077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418232.2 enterobacterial common antigen polysaccharide co-polymerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418232.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3IUK6, A0A1X3JA10, A0A5B9AR56, A0A7H9SIT9, A0A8S7CQX5, C3SKP2, D3H3Z4
    Conserved Domains (1) summary
    PRK11638
    Location:8 → 348
    PRK11638; ECA polysaccharide chain length modulation protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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