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nhaB Na(+):H(+) antiporter NhaB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944822, updated on 3-Dec-2024

Summary

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Official Symbol
nhaB
Official Full Name
Na(+):H(+) antiporter NhaB
Primary source
ECOCYC:EG11392
Locus tag
b1186
See related
ASAP:ABE-0003984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1174
Summary
NhaB, but not NhaA, is inhibited by the diuretic drugs amiloride and harmaline. [More information is available at EcoGene: EG11392]. NhaB is one of the three known sodium ion/proton antiporters in Escherichia coli along with NhaA and ChaA, though there are other mechanisms for Na+ extrusion such as NDH-I complicating the determination of the precise roles of each of the transporters. [More information is available at EcoCyc: EG11392].
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Genomic context

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Sequence:
NC_000913.3 (1233176..1234717, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase V protein UmuD Neighboring gene DNA polymerase V catalytic protein Neighboring gene protein thiol:quinone oxidoreductase DsbB Neighboring gene DNA-binding transcriptional dual regulator FadR Neighboring gene PF04293 family protein YcgB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and properties of a mutant of Escherichia coli possessing defective Na+/H+ antiporter. Ishikawa T, et al. J Biol Chem, 1987 Jun 5. PMID 3034895
  2. Monomers of the NhaA Na+/H+ antiporter of Escherichia coli are fully functional yet dimers are beneficial under extreme stress conditions at alkaline pH in the presence of Na+ or Li+. Rimon A, et al. J Biol Chem, 2007 Sep 14. PMID 17635927
  3. Properties of recombinant cells capable of growing on serine without NhaB Na+/H+ antiporter in Escherichia coli. Kayahara T, et al. J Bacteriol, 1992 Nov. PMID 1331028, Free PMC Article
  4. Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli. Thelen P, et al. J Bacteriol, 1991 Oct. PMID 1655717, Free PMC Article
  5. Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter system(s). Padan E, et al. J Biol Chem, 1989 Dec 5. PMID 2555351

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to lithium ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Na(+):H(+) antiporter NhaB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1233176..1234717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415704.1 Na(+):H(+) antiporter NhaB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415704.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JX70, A0A377DEG2
    Conserved Domains (1) summary
    PRK09547
    Location:1 → 510
    nhaB; sodium/proton antiporter NhaB
Nucleotide Protein
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