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mutT 8-oxo-dGTP diphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944824, updated on 3-Dec-2024

Summary

Official Symbol
mutT
Official Full Name
8-oxo-dGTP diphosphatase
Primary source
ECOCYC:EG10626
Locus tag
b0099
See related
ASAP:ABE-0000346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0100; nudA
Summary
Nudix hydrolase. [More information is available at EcoGene: EG10626]. dGTP pyrophosphohydrolase (MutT) can catalyze the hydrolysis of all eight canonical nucleotides, but it shows a marked preference for dGTP. [More information is available at EcoCyc: EG10626].
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Genomic context

Sequence:
NC_000913.3 (111044..111433)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene SecA translation regulator Neighboring gene protein translocation ATPase Neighboring gene DNA gyrase inhibitor YacG Neighboring gene cell division factor ZapD Neighboring gene dephospho-CoA kinase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables 8-oxo-GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-oxo-GDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-oxo-GDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables 8-oxo-dGDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-oxo-dGDP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 8-oxo-dGDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables ATP diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair EXP
Inferred from Experiment
more info
PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair IC
Inferred by Curator
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dGDP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dGTP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
8-oxo-dGTP diphosphatase
NP_414641.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    111044..111433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414641.1 8-oxo-dGTP diphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414641.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6D0IYI2, A0A8T6BV79
    Conserved Domains (1) summary
    PRK10776
    Location:1129
    PRK10776; 8-oxo-dGTP diphosphatase MutT