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gcd quinoprotein glucose dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944830, updated on 17-Dec-2024

Summary

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Official Symbol
gcd
Official Full Name
quinoprotein glucose dehydrogenase
Primary source
ECOCYC:EG10369
Locus tag
b0124
See related
ASAP:ABE-0000433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0123
Summary
Glucose dehydrogenase (Gcd) is a membrane-bound enzyme. [More information is available at EcoCyc: EG10369].
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Genomic context

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Sequence:
NC_000913.3 (138835..141225, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipoprotein YacC Neighboring gene multicopper oxidase CueO Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene carbonic anhydrase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetics and thermodynamics of activation of quinoprotein glucose dehydrogenase apoenzyme in vivo and catalytic activity of the activated enzyme in Escherichia coli cells. Iswantini D, et al. Biochem J, 2000 Sep 15. PMID 10970809, Free PMC Article
  2. Cloning, mapping, and sequencing of the gene encoding Escherichia coli quinoprotein glucose dehydrogenase. Cleton-Jansen AM, et al. J Bacteriol, 1990 Nov. PMID 2228962, Free PMC Article
  3. Enzymatic determination of pyrroloquinoline quinone using crude membranes from Escherichia coli. Geiger O, et al. Anal Biochem, 1987 Aug 1. PMID 3118738
  4. Energy transduction by electron transfer via a pyrrolo-quinoline quinone-dependent glucose dehydrogenase in Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus (var. lwoffi). van Schie BJ, et al. J Bacteriol, 1985 Aug. PMID 3926746, Free PMC Article
  5. Effect of PQQ glucose dehydrogenase overexpression in Escherichia coli on sugar-dependent respiration. Sode K, et al. J Biotechnol, 1995 Nov 21. PMID 8573321

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Topological analysis of quinoprotein glucose dehydrogenase in Escherichia coli and its ubiquinone-binding site.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyrroloquinoline quinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables quinoprotein glucose dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinoprotein glucose dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables quinoprotein glucose dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within non-phosphorylated glucose catabolic process EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
quinoprotein glucose dehydrogenase
NP_414666.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    138835..141225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414666.1 quinoprotein glucose dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414666.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N2YCZ6
    Conserved Domains (1) summary
    COG4993
    Location:11 → 793
    Gcd; Glucose dehydrogenase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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