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can carbonic anhydrase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944832, updated on 3-Dec-2024

Summary

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Official Symbol
can
Official Full Name
carbonic anhydrase 2
Primary source
ECOCYC:EG12319
Locus tag
b0126
See related
ASAP:ABE-0000442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0125; yadF
Summary
can forms a synthetic lethal with cynT, rescued by high CO2. [More information is available at EcoGene: EG12319]. Escherichia coli encodes two carbonic anhydrases, Can (carbonic anhydrase 2) and CynT (carbonic anhydrase 1). [More information is available at EcoCyc: EG12319].
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Genomic context

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Sequence:
NC_000913.3 (142008..142670, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene quinoprotein glucose dehydrogenase Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene putative ABC transporter ATP-binding protein YadG Neighboring gene putative ABC transporter membrane subunit YadH Neighboring gene putative PTS enzyme IIA component YadI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity. Cronk JD, et al. Protein Sci, 2001 May. PMID 11316870, Free PMC Article
  2. Cloning, crystallization and preliminary characterization of a beta-carbonic anhydrase from Escherichia coli. Cronk JD, et al. Acta Crystallogr D Biol Crystallogr, 2000 Sep. PMID 10957638
  3. Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase. Cronk JD, et al. Biochemistry, 2006 Apr 11. PMID 16584170
  4. Bacterial carbonic anhydrases. Kozliak EI, et al. EXS, 2000. PMID 11268536
  5. Indispensability of the Escherichia coli carbonic anhydrases YadF and CynT in cell proliferation at a low CO2 partial pressure. Hashimoto M, et al. Biosci Biotechnol Biochem, 2003 Apr. PMID 12784642

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonate dehydratase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbon utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbon utilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carbonic anhydrase 2
NP_414668.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    142008..142670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414668.1 carbonic anhydrase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414668.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3R0MWD7
    Conserved Domains (1) summary
    PRK10437
    Location:1 → 220
    PRK10437; carbonic anhydrase; Provisional
Nucleotide Protein
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