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erpA iron-sulfur cluster insertion protein ErpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944857, updated on 3-Dec-2024

Summary

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Official Symbol
erpA
Official Full Name
iron-sulfur cluster insertion protein ErpA
Primary source
ECOCYC:EG12332
Locus tag
b0156
See related
ASAP:ABE-0000538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0155; yadR
Summary
ErpA is required for respiratory growth and erpA mutants have reduced ubiquinone and menaquinone and can transfer Fe-S clusters to apo-IspG (Loiseau, 2007). iscA, sufA, erpA, and nfuA are paralogs. [More information is available at EcoGene: EG12332]. ErpA is an A-type iron-sulfur protein; it can bind both [2Fe-2S] and [4Fe-4S] clusters. [More information is available at EcoCyc: EG12332].
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Genomic context

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Sequence:
NC_000913.3 (176610..176954)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YadX Neighboring gene chloride:H(+) antiporter ClcA Neighboring gene protein YadW Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ErpA/NfuA complex builds an oxidation-resistant Fe-S cluster delivery pathway. Py B, et al. J Biol Chem, 2018 May 18. PMID 29626095, Free PMC Article
  2. A-type carrier protein ErpA is essential for formation of an active formate-nitrate respiratory pathway in Escherichia coli K-12. Pinske C, et al. J Bacteriol, 2012 Jan. PMID 22081393, Free PMC Article
  3. Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress. Fisher CE, et al. J Biol Chem, 2024 Aug. PMID 38944118, Free PMC Article
  4. ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. Loiseau L, et al. Proc Natl Acad Sci U S A, 2007 Aug 21. PMID 17698959, Free PMC Article
  5. Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers. Vinella D, et al. PLoS Genet, 2009 May. PMID 19478995, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress.
    Title: Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress.
  2. These findings suggest that ErpA and IscA have overlapping roles in assembly of these anaerobic respiratory enzymes but demonstrate that ErpA is essential for the production of active enzymes.
    Title: A-type carrier protein ErpA is essential for formation of an active formate-nitrate respiratory pathway in Escherichia coli K-12.
  3. Under aerobiosis, IscA and SufA are functionally redundant carriers and both can receive an Fe/S cluster from IscU.
    Title: Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anaerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein maturation by [4Fe-4S] cluster transfer IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein maturation by [4Fe-4S] cluster transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
iron-sulfur cluster insertion protein ErpA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    176610..176954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414698.1 iron-sulfur cluster insertion protein ErpA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414698.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APL5
    Conserved Domains (1) summary
    PRK13623
    Location:1 → 114
    PRK13623; iron-sulfur cluster insertion protein ErpA; Provisional
Nucleotide Protein
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