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glnD protein-PII uridylyltransferase/uridylyl-removing enzyme [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944863, updated on 3-Dec-2024

Summary

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Official Symbol
glnD
Official Full Name
protein-PII uridylyltransferase/uridylyl-removing enzyme
Primary source
ECOCYC:EG11411
Locus tag
b0167
See related
ASAP:ABE-0000568
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0165; glnD5
Summary
GlnD has both a uridylyltransferase and a uridylyl-removing activity. [More information is available at EcoGene: EG11411]. Uridylyltransferase is a single polypeptide chain. [More information is available at EcoCyc: EG11411].
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Genomic context

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Sequence:
NC_000913.3 (185978..188650, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphodiesterase YaeI Neighboring gene tetrahydrodipicolinate succinylase Neighboring gene methionine aminopeptidase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of glutamine synthetase formation in Escherichia coli: characterization of mutants lacking the uridylyltransferase. Bloom FR, et al. J Bacteriol, 1978 May. PMID 26660, Free PMC Article
  2. Localization of the glnD gene on a revised map of the 200-kilobase region of the Escherichia coli chromosome. van Heeswijk W, et al. J Bacteriol, 1992 Mar. PMID 1537813, Free PMC Article
  3. The Escherichia coli PII signal transduction protein is activated upon binding 2-ketoglutarate and ATP. Kamberov ES, et al. J Biol Chem, 1995 Jul 28. PMID 7629080
  4. Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme. Garcia E, et al. J Biol Chem, 1983 Feb 25. PMID 6130097
  5. Characterization of a gene, glnL, the product of which is involved in the regulation of nitrogen utilization in Escherichia coli. Chen YM, et al. J Bacteriol, 1982 Apr. PMID 6120930, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-gamma-glutamate synthase FolC.
    Title: The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-γ-glutamate synthase FolC.
  2. investigation of regulation of UR-PII-ATase-GS bicyclic system: Data suggest that AT activity is only bound/activated by completely unmodified PII and that this design is largely responsible for ultrasensitivity of bicyclic system.
    Title: A source of ultrasensitivity in the glutamine response of the bicyclic cascade system controlling glutamine synthetase adenylylation state and activity in Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables [protein-PII] uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [protein-PII] uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [protein-PII] uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [protein-PII] uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of nitrogen utilization EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of nitrogen utilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
protein-PII uridylyltransferase/uridylyl-removing enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    185978..188650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414709.1 protein-PII uridylyltransferase/uridylyl-removing enzyme [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414709.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QVZ6
    Conserved Domains (1) summary
    PRK05007
    Location:7 → 890
    PRK05007; bifunctional uridylyltransferase/uridylyl-removing protein GlnD
Nucleotide Protein
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