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yafN antitoxin YafN [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944920, updated on 3-Dec-2024

Summary

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Official Symbol
yafN
Official Full Name
antitoxin YafN
Primary source
ECOCYC:G6116
Locus tag
b0232
See related
ASAP:ABE-0000793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0233
Summary
YafN is an StbD homolog and a distant homolog of DnaT. [More information is available at EcoGene: EG13151]. Polar dinB mutations affecting the dinB-yafN-yafO-yafP operon reduce spontaneous mutagenesis . [More information is available at EcoCyc: G6116].
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Genomic context

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Sequence:
NC_000913.3 (252005..252298)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DNA polymerase IV Neighboring gene ribosome-dependent mRNA interferase toxin YafO Neighboring gene putative N-acetyltransferase YafP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli. Zhang F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Aug 1. PMID 22869116, Free PMC Article
  2. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Courcelle J, et al. Genetics, 2001 May. PMID 11333217, Free PMC Article
  3. The dinB operon and spontaneous mutation in Escherichia coli. McKenzie GJ, et al. J Bacteriol, 2003 Jul. PMID 12813093, Free PMC Article
  4. The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Gotfredsen M, et al. Mol Microbiol, 1998 Aug. PMID 9767574
  5. Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. Gerdes K. J Bacteriol, 2000 Feb. PMID 10633087, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in SOS response IEA
Inferred from Electronic Annotation
more info
  
involved_in SOS response NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
antitoxin YafN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    252005..252298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414767.1 antitoxin YafN [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414767.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9AAI8
    Conserved Domains (1) summary
    PRK09778
    Location:1 → 97
    PRK09778; type I toxin-antitoxin system antitoxin YafN
Nucleotide Protein
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