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prpB 2-methylisocitrate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944990, updated on 3-Dec-2024

Summary

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Official Symbol
prpB
Official Full Name
2-methylisocitrate lyase
Primary source
ECOCYC:G6196
Locus tag
b0331
See related
ASAP:ABE-0001138
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0329; yahQ
Summary
Repressed during biofilm formation. [More information is available at EcoGene: EG13601]. PrpB catalyzes the final step in the propionate metabolism pathway . [More information is available at EcoCyc: G6196].
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Genomic context

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Sequence:
NC_000913.3 (348682..349572)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing protein YahO Neighboring gene DNA-binding transcriptional dual regulator PrpR Neighboring gene 2-methylcitrate synthase Neighboring gene 2-methylcitrate dehydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. Liu S, et al. Biochemistry, 2005 Mar 1. PMID 15723538
  2. Crystal structure of Salmonella typhimurium 2-methylisocitrate lyase (PrpB) and its complex with pyruvate and Mg(2+). Simanshu DK, et al. Biochem Biophys Res Commun, 2003 Nov 7. PMID 14575713
  3. Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre. Grimm C, et al. J Mol Biol, 2003 May 2. PMID 12706720
  4. 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes. Brock M, et al. Eur J Biochem, 2001 Jun. PMID 11422389
  5. Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein. Lee SK, et al. J Bacteriol, 2005 Apr. PMID 15805526, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylisocitrate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylisocitrate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylisocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in propionate catabolic process, 2-methylcitrate cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within propionate catabolic process, 2-methylcitrate cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in propionate catabolic process, 2-methylcitrate cycle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-methylisocitrate lyase
NP_414865.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    348682..349572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414865.1 2-methylisocitrate lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414865.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GDI3
    Conserved Domains (1) summary
    PRK11320
    Location:2 → 292
    prpB; 2-methylisocitrate lyase; Provisional
Nucleotide Protein
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