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dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945019, updated on 17-Dec-2024

Summary

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Official Symbol
dxr
Official Full Name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Primary source
ECOCYC:EG12715
Locus tag
b0173
See related
ASAP:ABE-0000592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0172; ispC; yaeM
Summary
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) catalyzes the first committed step in the methylerythritol phosphate pathway of isoprenoid biosynthesis. [More information is available at EcoCyc: EG12715].
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Genomic context

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Sequence:
NC_000913.3 (193521..194717)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UMP kinase Neighboring gene ribosome-recycling factor Neighboring gene ncRNA Neighboring gene ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Mercklé L, et al. Chembiochem, 2005 Oct. PMID 16116659
  2. Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. Yajima S, et al. J Biochem, 2002 Mar. PMID 11872159
  3. Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Hoeffler JF, et al. Eur J Biochem, 2002 Sep. PMID 12230556
  4. Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. Steinbacher S, et al. J Biol Chem, 2003 May 16. PMID 12621040
  5. High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition. Gottlin EB, et al. J Biomol Screen, 2003 Jun. PMID 12857387

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
    Title: Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
  2. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative.
    Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
  3. chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase
    Title: The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Dxr protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
1-deoxy-D-xylulose 5-phosphate reductoisomerase
NP_414715.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    193521..194717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414715.1 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414715.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5GZ07, A0A5B9AL13, A0A8S7RUP4
    Conserved Domains (1) summary
    TIGR00243
    Location:1 → 398
    Dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Nucleotide Protein
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