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phoR sensor histidine kinase PhoR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945044, updated on 3-Dec-2024

Summary

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Official Symbol
phoR
Official Full Name
sensor histidine kinase PhoR
Primary source
ECOCYC:EG10733
Locus tag
b0400
See related
ASAP:ABE-0001391
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0394; nmpB; phoR1; R1pho
Summary
Phosphate regulon sensor kinase-phosphotransferase PhoR is probably a dimer or higher oligomer. [More information is available at EcoCyc: EG10733].
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Genomic context

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Sequence:
NC_000913.3 (417889..419184)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcC subunit Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcD subunit Neighboring gene DNA-binding transcriptional dual regulator PhoB Neighboring gene branched chain amino acid transporter BrnQ Neighboring gene putative transporter ProY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of the phosphate regulon of Escherichia coli: properties of phoR deletion mutants and subcellular localization of PhoR protein. Yamada M, et al. Mol Gen Genet, 1990 Feb. PMID 2187152
  2. The phosphotransferase protein EIIA(Ntr) modulates the phosphate starvation response through interaction with histidine kinase PhoR in Escherichia coli. Lüttmann D, et al. Mol Microbiol, 2012 Oct. PMID 22812494
  3. Transcriptome analysis of phosphate starvation response in Escherichia coli. Baek JH, et al. J Microbiol Biotechnol, 2007 Feb. PMID 18051755
  4. Genetic mapping of the phoR regulator gene of alkaline phosphatase in Escherichia coli. Bracha M, et al. J Gen Microbiol, 1969 Nov. PMID 4903904
  5. Outer membrane protein e of Escherichia coli K-12 is co-regulated with alkaline phosphatase. Tommassen J, et al. J Bacteriol, 1980 Jul. PMID 6995425, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PhoU interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.
    Title: The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.
  2. Findings indicate that the mode of autophosphorylation is highly conserved and that orthologs of EnvZ and PhoR with diverse loops autophosphorylated in trans and in cis, respectively.
    Title: Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.
  3. Protein interaction analyses reveal binding of EIIA(Ntr) to histidine kinase PhoR.
    Title: The phosphotransferase protein EIIA(Ntr) modulates the phosphate starvation response through interaction with histidine kinase PhoR in Escherichia coli.
  4. CreC showed an interaction with PhoB, before an interaction between PhoB and PhoR, suggesting that this acts as a constant sensor for the early response to phosphate starvation.
    Title: Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphorelay sensor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to phosphate starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sensor histidine kinase PhoR
NP_414934.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    417889..419184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414934.1 sensor histidine kinase PhoR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414934.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X2I4
    Conserved Domains (1) summary
    PRK11006
    Location:1 → 430
    phoR; phosphate regulon sensor histidine kinase PhoR
Nucleotide Protein
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