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cyoA cytochrome bo3 subunit 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945080, updated on 3-Dec-2024

Summary

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Official Symbol
cyoA
Official Full Name
cytochrome bo3 subunit 2
Primary source
ECOCYC:EG10178
Locus tag
b0432
See related
ASAP:ABE-0001495
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0426
Summary
2 IM TMS; cleavable signal peptide can be incorrectly predicted as a third TMS. [More information is available at EcoGene: EG10178]. CyoA is subunit II of the cytochrome bo terminal oxidase complex encoded by cyoABCDE. [More information is available at EcoCyc: EG10178].
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Genomic context

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Sequence:
NC_000913.3 (450663..451610, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bo3 subunit 4 Neighboring gene cytochrome bo3 subunit 3 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene muropeptide:H(+) symporter Neighboring gene putative lipoprotein YajG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex. van der Oost J, et al. J Mol Biol, 1993 Feb 5. PMID 8433374
  2. Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center. Wilmanns M, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618822, Free PMC Article
  3. Glutamate-89 in subunit II of cytochrome bo3 from Escherichia coli is required for the function of the heme-copper oxidase. Ma J, et al. Biochemistry, 1999 Nov 16. PMID 10563797
  4. Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases. Mogi T, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111521
  5. Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA. van Bloois E, et al. J Biol Chem, 2006 Apr 14. PMID 16481320

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. No evidence of low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli.
    Title: Searching for the low affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli.
  2. Data suggest that in RsCcO(aa3), the E286 mutations severely perturb the active site, while he local structure around E286 in EcQO(bo3) is different, providing a rationale for the different effects of E286 mutations in the two enzymes.
    Title: Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
  3. Removal of three terminal cytochrome oxidase genes (cydAB, cyoABCD, and cbdAB) and a quinol monooxygenase gene (ygiN) from the Escherichia coli K-12 MG1655 genome resulted in the activation of ArcA aerobically.
    Title: Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655.
  4. analysis of translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA
    Title: Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.
  5. Data show that the distinct domains of CyoA have different translocation requirements (YidC only and Sec/YidC) and confirms that the membrane biogenesis of subunit II of cytochrome oxidase in bacteria and mitochondria have conserved features.
    Title: Membrane biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for insertion of N-terminal and C-terminal domains.
  6. CyoA is a substrate of a novel pathway that involves both SecYEG and YidC
    Title: Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cytochrome bo3 ubiquinol oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytochrome bo3 ubiquinol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreduction-driven active transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within aerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within electron transport coupled proton transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in electron transport coupled proton transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of cytochrome o ubiquinol oxidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytochrome o ubiquinol oxidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
cytochrome bo3 subunit 2
NP_414966.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    450663..451610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414966.1 cytochrome bo3 subunit 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414966.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3LGY6
    Conserved Domains (1) summary
    PRK10525
    Location:1 → 315
    PRK10525; cytochrome o ubiquinol oxidase subunit II; Provisional
Nucleotide Protein
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