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cof HMP-PP phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945089, updated on 3-Dec-2024

Summary

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Official Symbol
cof
Official Full Name
HMP-PP phosphatase
Primary source
ECOCYC:G6246
Locus tag
b0446
See related
ASAP:ABE-0001548
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0440
Summary
Cloned cof complements fur deletion mutant for growth on succinate: this gene name and function have only been reported as an annotation in EMBL entry Z54355, Patzer, S.I. and Hantke, K., 1995. [More information is available at EcoGene: EG13216]. Cof is a phosphatase belonging to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: G6246].
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Genomic context

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Sequence:
NC_000913.3 (467412..468230)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7-cyano-7-deazaguanine synthase Neighboring gene uncharacterized protein YbaE Neighboring gene DNA-binding transcriptional activator DecR Neighboring gene ABC transporter family protein MdlA Neighboring gene ABC transporter family protein MdlB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen for the identification of thiamin metabolic genes. Lawhorn BG, et al. J Biol Chem, 2004 Oct 15. PMID 15292217
  2. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article
  3. Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. Kuznetsova E, et al. J Biol Chem, 2006 Nov 24. PMID 16990279
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibiotic catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thiamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
HMP-PP phosphatase
NP_414980.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    467412..468230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414980.2 HMP-PP phosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414980.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WVG4, A0A6N8R372
    Conserved Domains (1) summary
    PRK15126
    Location:1 → 272
    PRK15126; HMP-PP phosphatase
Nucleotide Protein
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