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tomB Hha toxicity modulator TomB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945106, updated on 3-Dec-2024

Summary

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Official Symbol
tomB
Official Full Name
Hha toxicity modulator TomB
Primary source
ECOCYC:EG12429
Locus tag
b0461
See related
ASAP:ABE-0001596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0455; ybaJ
Summary
Induced during biofilm formation. [More information is available at EcoGene: EG12429]. The tomB-hha operon may encode an antitoxin-toxin module. [More information is available at EcoCyc: EG12429].
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Genomic context

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Sequence:
NC_000913.3 (480334..480708, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose O-acetyltransferase Neighboring gene hemolysin expression-modulating protein Hha Neighboring gene multidrug efflux pump RND permease AcrB Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An oxygen-sensitive toxin-antitoxin system. Marimon O, et al. Nat Commun, 2016 Dec 8. PMID 27929062, Free PMC Article
  2. The hha gene modulates haemolysin expression in Escherichia coli. Nieto JM, et al. Mol Microbiol, 1991 May. PMID 1956303
  3. Hha, YbaJ, and OmpA regulate Escherichia coli K12 biofilm formation and conjugation plasmids abolish motility. Barrios AF, et al. Biotechnol Bioeng, 2006 Jan 5. PMID 16317765
  4. Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes. García-Contreras R, et al. PLoS One, 2008 Jun 11. PMID 18545668, Free PMC Article
  5. Transcriptional response of Escherichia coli to external copper. Yamamoto K, et al. Mol Microbiol, 2005 Apr. PMID 15773991

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within single-species biofilm formation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hha toxicity modulator TomB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    480334..480708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414994.1 Hha toxicity modulator TomB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414994.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MYL7
    Conserved Domains (1) summary
    PRK10667
    Location:1 → 122
    PRK10667; Hha toxicity modulator TomB
Nucleotide Protein
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