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loiP metalloprotease LoiP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945173, updated on 3-Dec-2024

Summary

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Official Symbol
loiP
Official Full Name
metalloprotease LoiP
Primary source
ECOCYC:EG11291
Locus tag
b2936
See related
ASAP:ABE-0009629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2931; yggG
Summary
The heat shock protein YggG binds Era and mitigates the deleterious effect of overproducing mutant Era-1 protein (Huang, 2007). htpX, yggG, yfgC and ycaL are paralogs. [More information is available at EcoGene: EG11291]. YggG protein interacts directly with Era, an essential GTPase . [More information is available at EcoCyc: EG11291].
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Genomic context

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Sequence:
NC_000913.3 (3081913..3082671)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannitol-specific PTS enzyme IIA component CmtB Neighboring gene transketolase 1 Neighboring gene agmatinase Neighboring gene biosynthetic arginine decarboxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [The expression of truncated YggG protein and preparation of its polyclonal antibody]. Huang Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2004 Mar. PMID 15191718
  2. Influence of cyclic AMP, agmatine, and a novel protein encoded by a flanking gene on speB (agmatine ureohydrolase) in Escherichia coli. Szumanski MB, et al. J Bacteriol, 1992 Feb. PMID 1310091, Free PMC Article
  3. Analysis and sequence of the speB gene encoding agmatine ureohydrolase, a putrescine biosynthetic enzyme in Escherichia coli. Szumanski MB, et al. J Bacteriol, 1990 Feb. PMID 2153656, Free PMC Article
  4. Introduction of a stress-responsive gene, yggG, enhances the yield of L-phenylalanine with decreased acetic acid production in a recombinant Escherichia coli. Ojima Y, et al. Biotechnol Lett, 2009 Apr. PMID 19125225
  5. Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. Sakoh M, et al. J Biol Chem, 2005 Sep 30. PMID 16076848

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We report that YggG of E. coli is a metalloprotease that cleaves its targets preferentially between Phe-Phe residues.
    Title: E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds.
  2. The expression regulation of the yggG gene under stress conditions and the YggG protein located on cell membrane are consistent with the bioinformatics analysis that YggG is functional as a heat shock protein that is associated with Era functions.
    Title: Expression and regulation of the yggG gene of Escherichia coli.
  3. The results indicated that YggG expression is significantly increased in response to stress caused by the Era-1 mutant protein in E. coli, thus promoting the growth of E. coli.
    Title: Up-regulation of yggG promotes the survival of Escherichia coli cells containing Era-1 mutant protein.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular hypotonic response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
metalloprotease LoiP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3081913..3082671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417411.2 metalloprotease LoiP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417411.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5YLC5
    Conserved Domains (1) summary
    cd07334
    Location:30 → 245
    M48C_loiP_like; Peptidase M48C Ste24p loiP-like, integral membrane protein
Nucleotide Protein
Heading Accession and Version

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