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fepE polysaccharide co-polymerase family protein FepE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945180, updated on 17-Dec-2024

Summary

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Official Symbol
fepE
Official Full Name
polysaccharide co-polymerase family protein FepE
Primary source
ECOCYC:EG10297
Locus tag
b0587
See related
ASAP:ABE-0002023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0580
Summary
FepE is believed to be a component of the ferric enterobactin transport system, because mutation of fepE disrupts uptake of enterobactin . [More information is available at EcoCyc: EG10297].
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Genomic context

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Sequence:
NC_000913.3 (618254..619387)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric enterobactin esterase Neighboring gene enterobactin biosynthesis protein YbdZ Neighboring gene apo-serine activating enzyme Neighboring gene ferric enterobactin ABC transporter ATP binding subunit Neighboring gene ferric enterobactin ABC transporter membrane subunit FepG Neighboring gene ferric enterobactin ABC transporter membrane subunit FebD Neighboring gene enterobactin exporter EntS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence-structure relationships in polysaccharide co-polymerase (PCP) proteins. Morona R, et al. Trends Biochem Sci, 2009 Feb. PMID 19058968
  2. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length. Tocilj A, et al. Nat Struct Mol Biol, 2008 Feb. PMID 18204465
  3. Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. Rusnak F, et al. Biochemistry, 1991 Mar 19. PMID 1826089
  4. Promoter and operator determinants for fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. Hunt MD, et al. J Bacteriol, 1994 Jul. PMID 8021177, Free PMC Article
  5. Inducible serum resistance in Salmonella typhimurium is dependent on wzz(fepE)-regulated very long O antigen chains. Murray GL, et al. Microbes Infect, 2005 Oct. PMID 16027021

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferric-enterobactin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ferric-enterobactin import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polysaccharide co-polymerase family protein FepE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    618254..619387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415119.1 polysaccharide co-polymerase family protein FepE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415119.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    W1F3A7
    Conserved Domains (1) summary
    PRK10381
    Location:1 → 377
    PRK10381; LPS O-antigen length regulator; Provisional
Nucleotide Protein
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