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cusA copper/silver export system RND permease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945191, updated on 3-Dec-2024

Summary

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Official Symbol
cusA
Official Full Name
copper/silver export system RND permease
Primary source
ECOCYC:EG12367
Locus tag
b0575
See related
ASAP:ABE-0001971
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0567; ybdE
Summary
cusA is in the cusCFBA Cu and Ag efflux operon regulated by Cu and Ag. [More information is available at EcoGene: EG12367]. CusA is a member of the Resistance-Nodulation-Cell Division (RND) Transporter Superfamily and is involved in the detoxification of copper and silver ions in Escherichia coli as part of the CusCFBA copper/silver efflux system. [More information is available at EcoCyc: EG12367].
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Genomic context

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Sequence:
NC_000913.3 (598714..601857)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper/silver export system periplasmic binding protein Neighboring gene copper/silver export system membrane fusion protein Neighboring gene phenylalanine:H(+) symporter PheP Neighboring gene miniconductance mechanosensitive channel YbdG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export. Moseng MA, et al. mBio, 2021 Apr 5. PMID 33820823, Free PMC Article
  2. Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Long F, et al. Nature, 2010 Sep 23. PMID 20865003, Free PMC Article
  3. Differences between CusA and AcrB crystallisation highlighted by protein flexibility. Deniaud A, et al. PLoS One, 2009 Jul 10. PMID 19593437, Free PMC Article
  4. Alternative periplasmic copper-resistance mechanisms in Gram negative bacteria. Pontel LB, et al. Mol Microbiol, 2009 Jul. PMID 19538445
  5. Cloning and sequencing of the pheP gene, which encodes the phenylalanine-specific transport system of Escherichia coli. Pi J, et al. J Bacteriol, 1991 Jun. PMID 1711024, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export.
    Title: Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export.
  2. CusA forms a mixture of quaternary structures (from monomer to heavy oligomer) in detergent solution.
    Title: Oligomeric behavior of the RND transporters CusA and AcrB in micellar solution of detergent.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables copper ion binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables copper ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables silver ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion export IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in copper ion export NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in copper ion transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in copper ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detoxification of copper ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plasma membrane copper ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to silver ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to silver ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to toxic substance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in silver ion transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within silver ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
copper/silver export system RND permease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    598714..601857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415107.1 copper/silver export system RND permease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415107.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5YGB6
    Conserved Domains (1) summary
    TIGR00914
    Location:1 → 1047
    2A0601; heavy metal efflux pump, CzcA family
Nucleotide Protein
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