U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ahpC alkyl hydroperoxide reductase, AhpC component [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945225, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ahpC
Official Full Name
alkyl hydroperoxide reductase, AhpC component
Primary source
ECOCYC:EG11384
Locus tag
b0605
See related
ASAP:ABE-0002090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0599; ssi8; tpx
Summary
AhpCF protects aerobic, phosphate-starved cells from oxidative damage. [More information is available at EcoGene: EG11384]. The AhpC component carries out the actual reduction of the hydroperoxide substrate. [More information is available at EcoCyc: EG11384].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (638945..639508)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative LysR family DNA-binding transcriptional regulator YbdO Neighboring gene protein sulfenic acid reductase and chaperone DsbG Neighboring gene alkyl hydroperoxide reductase, AhpF component Neighboring gene universal stress protein G

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress. Dip PV, et al. Biochim Biophys Acta, 2014 Dec. PMID 25193562
  2. AhpC is required for optimal production of enterobactin by Escherichia coli. Ma L, et al. J Bacteriol, 2012 Dec. PMID 23042987, Free PMC Article
  3. Structure, mechanism and ensemble formation of the alkylhydroperoxide reductase subunits AhpC and AhpF from Escherichia coli. Dip PV, et al. Acta Crystallogr D Biol Crystallogr, 2014 Nov. PMID 25372677
  4. Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases. Poole LB. Arch Biochem Biophys, 2005 Jan 1. PMID 15581580
  5. AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC. Poole LB, et al. Biochemistry, 2000 Jun 6. PMID 10828978

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a concerted movement involving the NTD, C-terminal NADH, and FAD domains, and the flexible linker between them in AhpF is essential for optimal intra-domain cross-talk and for efficient electron transfer to the redox partner AhpC required for peroxidation
    Title: Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxin.
  2. Data show that the very C-terminus of the oxidized alkyl hydroperoxide reductase C22 subunit AhpC is oriented away from the dimer interface and away from the catalytic redox-center.
    Title: Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress.
  3. AhpC is required for optimal production of enterobactin; data suggested that AhpC affected the activity of EntC or the availability of the chorismate substrate
    Title: AhpC is required for optimal production of enterobactin by Escherichia coli.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Indole-inducible proteins in bacteria suggest membrane and oxidant toxicity.
  5. Hpx- (katG katE ahpCF) mutants of Escherichia coli have DNA damage from submicromolar intracellular hydrogen peroxide
    Title: Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroperoxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity, acting on peroxide as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to sulfate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to alkyl hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in siderophore biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of alkyl hydroperoxide reductase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alkyl hydroperoxide reductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
alkyl hydroperoxide reductase, AhpC component
NP_415138.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    638945..639508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415138.1 alkyl hydroperoxide reductase, AhpC component [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415138.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AKJ5
    Conserved Domains (1) summary
    PRK10382
    Location:1 → 187
    PRK10382; alkyl hydroperoxide reductase subunit C; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.