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rlpA rare lipoprotein RlpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945241, updated on 3-Dec-2024

Summary

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Official Symbol
rlpA
Official Full Name
rare lipoprotein RlpA
Primary source
ECOCYC:EG10854
Locus tag
b0633
See related
ASAP:ABE-0002171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0626
Summary
First 17 aa are a type II signal peptide. [More information is available at EcoGene: EG10854]. RlpA is one of two (along with RlpB) so-called rare lipoproteins in Escherichia coli. [More information is available at EcoCyc: EG10854].
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Genomic context

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Sequence:
NC_000913.3 (664102..665190, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF493 domain-containing protein YbeD Neighboring gene D-alanyl-D-alanine carboxypeptidase DacA Neighboring gene peptidoglycan glycosyltransferase MrdB Neighboring gene peptidoglycan DD-transpeptidase MrdA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli. Berezuk AM, et al. Sci Rep, 2018 Aug 28. PMID 30154462, Free PMC Article
  2. The temperature sensitive mutant 72c. II. Accumulation at high temperature of ppGpp and pppGpp in the presence of protein synthesis. Takata R, et al. Mol Gen Genet, 1978 Apr 25. PMID 353496
  3. Self-enhanced accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR domain (DamX, DedD, and RlpA) in Escherichia coli cell constriction. Gerding MA, et al. J Bacteriol, 2009 Dec. PMID 19684127, Free PMC Article
  4. Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA. Arends SJ, et al. J Bacteriol, 2010 Jan. PMID 19880599, Free PMC Article
  5. Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains. Han MJ, et al. J Microbiol Biotechnol, 2012 Apr. PMID 22534293

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of rlpA from an FtsK temperature-sensitive E. coli strain partially restored cell growth and largely suppressed cellular filamentation compared to the wild-type strain. This suggests that interaction with RlpA may be critical in suppressing septation until proper assembly of the divisome.
    Title: Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
  2. Data show that RlpA proteins localize to the septal ring in E. coli.
    Title: Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lytic endotransglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rare lipoprotein RlpA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    664102..665190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415166.1 rare lipoprotein RlpA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415166.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q9E4
    Conserved Domains (1) summary
    PRK10672
    Location:1 → 362
    PRK10672; endolytic peptidoglycan transglycosylase RlpA
Nucleotide Protein
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