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mprA DNA-binding transcriptional regulator MprA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945282, updated on 17-Dec-2024

Summary

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Official Symbol
mprA
Official Full Name
DNA-binding transcriptional regulator MprA
Primary source
ECOCYC:EG10603
Locus tag
b2684
See related
ASAP:ABE-0008834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2678; emrR
Summary
The "Escherichia coli multidrug resistance regulator" , EmrR, negatively regulates the transcription of genes that code for multidrug resistance pumps that extrude structurally unrelated antimicrobial agents from the cell and possibly it also represses a gene that codes for a porin . [More information is available at EcoCyc: EG10603].
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Genomic context

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Sequence:
NC_000913.3 (2810770..2811300)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component Neighboring gene multidrug efflux pump membrane fusion protein EmrA Neighboring gene multidrug efflux pump membrane subunit EmrB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new family of low molecular weight antibiotics from enterobacteria. Asensio C, et al. Biochem Biophys Res Commun, 1976 Mar 8. PMID 4071
  2. mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid. del Castillo I, et al. J Bacteriol, 1990 Jan. PMID 2152912, Free PMC Article
  3. Overlaps and parallels in the regulation of intrinsic multiple-antibiotic resistance in Escherichia coli. Miller PF, et al. Mol Microbiol, 1996 Aug. PMID 8866468
  4. Expression of a Butyrivibrio fibrisolvens E14 gene (cinB) encoding an enzyme with cinnamoyl ester hydrolase activity is negatively regulated by the product of an adjacent gene (cinR). Dalrymple BP, et al. Microbiology (Reading), 1997 Apr. PMID 9141683
  5. Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria. Rodionov DA, et al. J Mol Microbiol Biotechnol, 2001 Apr. PMID 11321589

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polyamines are involved in easing of oxidative stress through stimulation of synthesis of SoxR, EmrR and GshA together with RpoS.
    Title: Three members of polyamine modulon under oxidative stress conditions: two transcription factors (SoxR and EmrR) and a glutathione synthetic enzyme (GshA).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional regulator MprA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2810770..2811300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417169.1 DNA-binding transcriptional regulator MprA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417169.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QFV1, W1EUT9
    Conserved Domains (1) summary
    PRK10870
    Location:1 → 176
    PRK10870; transcriptional repressor MprA; Provisional
Nucleotide Protein
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