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arnD putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945334, updated on 17-Dec-2024

Summary

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Official Symbol
arnD
Official Full Name
putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Primary source
ECOCYC:G7169
Locus tag
b2256
See related
ASAP:ABE-0007462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2249; pmrJ; yfbH
Summary
An arnD mutant strain accumulates formylated C55-P-LAra4N and blocks C55-P-LAra4N production, supporting the deformaylase functional assignment (S.D. [More information is available at EcoGene: EG14092]. ArnD is predicted to act as a deformylase that removes the formyl group from undecaprenyl phosphate-L-Ara4FN . [More information is available at EcoCyc: G7169].
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Genomic context

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Sequence:
NC_000913.3 (2370018..2370908)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-4-amino-4-deoxy-L-arabinose aminotransferase Neighboring gene undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The pleiotropic two-component regulatory system PhoP-PhoQ. Groisman EA. J Bacteriol, 2001 Mar. PMID 11222580, Free PMC Article
  2. Fe(III)-mediated cellular toxicity. Chamnongpol S, et al. Mol Microbiol, 2002 Aug. PMID 12139617
  3. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Gibbons HS, et al. Mol Microbiol, 2005 Jan. PMID 15659161
  4. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. Yan A, et al. J Biol Chem, 2007 Dec 7. PMID 17928292, Free PMC Article
  5. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. Trent MS, et al. J Biol Chem, 2001 Nov 16. PMID 11535605

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to iron(III) ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to iron(III) ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2370018..2370908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416759.1 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416759.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FPX7
    Conserved Domains (1) summary
    PRK15394
    Location:1 → 291
    PRK15394; 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional
Nucleotide Protein
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