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modE DNA-binding transcriptional dual regulator ModE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945366, updated on 3-Dec-2024

Summary

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Official Symbol
modE
Official Full Name
DNA-binding transcriptional dual regulator ModE
Primary source
ECOCYC:G6395
Locus tag
b0761
See related
ASAP:ABE-0002585
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlD; ECK0750; modR
Summary
ModE mutants are unable to reduce selenate. [More information is available at EcoGene: EG13227].
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Genomic context

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Sequence:
NC_000913.3 (793856..794644, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-glucose 4-epimerase Neighboring gene ABC family protein ModF Neighboring gene multidrug efflux pump accessory protein AcrZ Neighboring gene molybdate ABC transporter periplasmic binding protein Neighboring gene molybdate ABC transporter membrane subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Anaerobic regulation of the Escherichia coli dmsABC operon requires the molybdate-responsive regulator ModE. McNicholas PM, et al. Mol Microbiol, 1998 Jan. PMID 9466267
  2. Functional dissection of the molybdate-responsive transcription regulator, ModE, from Escherichia coli. McNicholas PM, et al. J Bacteriol, 1998 Sep. PMID 9721306, Free PMC Article
  3. Sensing of remote oxyanion binding at the DNA binding domain of the molybdate-dependent transcriptional regulator, ModE. Boxer DH, et al. Org Biomol Chem, 2004 Oct 7. PMID 15455157
  4. A DNA element recognised by the molybdenum-responsive transcription factor ModE is conserved in Proteobacteria, green sulphur bacteria and Archaea. Studholme DJ, et al. BMC Microbiol, 2003 Dec 2. PMID 14641908, Free PMC Article
  5. Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport. Gourley DG, et al. J Biol Chem, 2001 Jun 8. PMID 11259434

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdenum ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in molybdate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ModE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator ModE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    793856..794644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415282.1 DNA-binding transcriptional dual regulator ModE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415282.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1IZI1
    Conserved Domains (1) summary
    PRK10676
    Location:1 → 262
    PRK10676; DNA-binding transcriptional regulator ModE; Provisional
Nucleotide Protein
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