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ybhA pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945372, updated on 3-Dec-2024

Summary

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Official Symbol
ybhA
Official Full Name
pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase
Primary source
ECOCYC:EG11239
Locus tag
b0766
See related
ASAP:ABE-0002607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0755
Summary
HAD superfamily. [More information is available at EcoGene: EG11239]. YbhA is a promiscuous phosphatase belonging to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: EG11239].
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Genomic context

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Sequence:
NC_000913.3 (797613..798431, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdate ABC transporter periplasmic binding protein Neighboring gene molybdate ABC transporter membrane subunit Neighboring gene molybdate ABC transporter ATP binding subunit Neighboring gene 6-phosphogluconolactonase Neighboring gene putative DNA-binding transcriptional regulator YbhD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of YbhA as the pyridoxal 5'-phosphate (PLP) phosphatase in Escherichia coli: Importance of PLP homeostasis on the bacterial growth. Sugimoto R, et al. J Gen Appl Microbiol, 2018 Jan 15. PMID 29187681
  2. Metabolomics approach for enzyme discovery. Saito N, et al. J Proteome Res, 2006 Aug. PMID 16889420
  3. Cloning and nucleotide sequence of the chlD locus. Johann S, et al. J Bacteriol, 1987 May. PMID 3553151, Free PMC Article
  4. Regulation of the molybdate transport operon, modABCD, of Escherichia coli in response to molybdate availability. Rech S, et al. J Bacteriol, 1995 Feb. PMID 7860583, Free PMC Article
  5. Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. Brown G, et al. J Biol Chem, 2009 Feb 6. PMID 19073594, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sugar-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pyridoxal phosphate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase
NP_415287.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    797613..798431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415287.1 pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415287.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TPV3
    Conserved Domains (1) summary
    PRK10530
    Location:1 → 272
    PRK10530; pyridoxal phosphate (PLP) phosphatase; Provisional
Nucleotide Protein
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