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metK methionine adenosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945389, updated on 3-Dec-2024

Summary

Official Symbol
metK
Official Full Name
methionine adenosyltransferase
Primary source
ECOCYC:EG10589
Locus tag
b2942
See related
ASAP:ABE-0009650
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2937; metX
Summary
The adjacent ORF yqgD has been removed from EcoGene because it is very unlikely to be a gene; the limited conservation with Salmonella is apparently due to a pseudotranslation of the conserved metK CRP site, promoter and the metK 5' UTR. [More information is available at EcoGene: EG10589]. Methionine adenosyltransferase catalyzes the formation of the sulfonium compound S-adenosylmethionine. [More information is available at EcoCyc: EG10589].
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Genomic context

Sequence:
NC_000913.3 (3086706..3087860)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YqgG Neighboring gene protein YqgC Neighboring gene DUF2684 domain-containing protein YqgD Neighboring gene galactose:H(+) symporter Neighboring gene protein YggI

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methionine adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in S-adenosylmethionine cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methionine adenosyltransferase
NP_417417.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3086706..3087860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417417.1 methionine adenosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417417.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A485JD64
    Conserved Domains (1) summary
    PRK05250
    Location:3383
    PRK05250; S-adenosylmethionine synthetase; Validated