U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

aqpZ water channel AqpZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945497, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
aqpZ
Official Full Name
water channel AqpZ
Primary source
ECOCYC:EG13270
Locus tag
b0875
See related
ASAP:ABE-0002976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bniP; ECK0866
Summary
AqpZ-dependent water permeability increases as cells enter stationary phase. [More information is available at EcoGene: EG13270]. AqpZ is a water channel, or aquaporin, that allows bi-directional passive diffusion of water in Escherichia coli. [More information is available at EcoCyc: EG13270].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (915352..916047, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein S-nitrosylase Neighboring gene L-lysine/thialysine exporter Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX Neighboring gene ABC-type tripartite efflux pump membrane fusion protein Neighboring gene ABC-type tripartite efflux pump ATP binding/membrane subunit

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy. Tan H, et al. Biochim Biophys Acta Biomembr, 2022 Feb 1. PMID 34624277
  2. Isolation of a gene encoding nodulin-like intrinsic protein of Escherichia coli. Fushimi K, et al. Biochem Mol Biol Int, 1997 Apr. PMID 9137831
  3. The aquaporin-Z water channel gene of Escherichia coli: structure, organization and phylogeny. Calamita G, et al. Biol Cell, 1997 Aug. PMID 9468603
  4. Regulation of the Escherichia coli water channel gene aqpZ. Calamita G, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520416, Free PMC Article
  5. Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. Delamarche C, et al. J Bacteriol, 1999 Jul. PMID 10400575, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
    Title: Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
  2. Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
    Title: Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
  3. Induction of an immune response against AqpZ or its homologous regions can also trigger an autoimmune reaction against human Aqp4 and inflammation of the central nervous system.
    Title: Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica.
  4. Data show that the open and closed states of AqpZ directly relate to the side chain conformation of residue R189.
    Title: Water permeation dynamics of AqpZ: a tale of two states.
  5. biochemical analysis of permeability and solute transport characteristics of amphiphilic triblock-polymer vesicles containing the bacterial water-channel protein Aquaporin Z
    Title: Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z.
  6. analysis of of Escherichia coli aquaporin AqpZ and GlpF single-channel water permeabilities
    Title: Single-channel water permeabilities of Escherichia coli aquaporins AqpZ and GlpF.
  7. the 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regulate the preference for a hydrophobic or hydrophilic substrate
    Title: Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
  8. the difference in Arg-189 displacements is correlated with a strong electron density between first transmembrane helices of two open channels; the observed Arg-189 conformations are stabilized by asymmetrical subunit interactions in tAqpZ
    Title: Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in water transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in water transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
water channel AqpZ

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    915352..916047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415396.1 water channel AqpZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415396.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7IEG3
    Conserved Domains (1) summary
    PRK05420
    Location:1 → 231
    PRK05420; aquaporin Z; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.