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pyrD dihydroorotate dehydrogenase, type 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945556, updated on 3-Dec-2024

Summary

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Official Symbol
pyrD
Official Full Name
dihydroorotate dehydrogenase, type 2
Primary source
ECOCYC:EG10807
Locus tag
b0945
See related
ASAP:ABE-0003201
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0936
Summary
The enzyme is a membrane-bound flavoprotein. [More information is available at EcoCyc: EG10807].
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Genomic context

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Sequence:
NC_000913.3 (1004768..1005778)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbU Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene cell division protein ZapC Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dihydroorotate dehydrogenase of Escherichia coli. Jensen KF, et al. Methods Mol Biol, 2003. PMID 12824540
  2. The anaerobic oxidation of dihydroorotate by Escherichia coli K-12. Andrews S, et al. Biochim Biophys Acta, 1977 Oct 12. PMID 199252
  3. Dihydroorotate dehydrogenase (Escherichia coli). Karibian D. Methods Enzymol, 1978. PMID 211391
  4. Antigenic architecture of membrane vesicles from Escherichia coli. Owen P, et al. Biochemistry, 1979 Apr 17. PMID 218621
  5. Immunochemical analysis of inner and outer membranes of Escherichia coli by crossed immunoelectrophoresis. Smyth CJ, et al. J Bacteriol, 1978 Jan. PMID 338583, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
    Title: New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the pyrD gene of Escherichia coli and characterization of the flavoprotein dihydroorotate dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydroorotate dehydrogenase, type 2
NP_415465.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1004768..1005778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415465.1 dihydroorotate dehydrogenase, type 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415465.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AL41
    Conserved Domains (1) summary
    PRK05286
    Location:1 → 336
    PRK05286; quinone-dependent dihydroorotate dehydrogenase
Nucleotide Protein
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