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ycbX 6-N-hydroxylaminopurine resistance protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945563, updated on 3-Dec-2024

Summary

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Official Symbol
ycbX
Official Full Name
6-N-hydroxylaminopurine resistance protein
Primary source
ECOCYC:G6487
Locus tag
b0947
See related
ASAP:ABE-0003206
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0938
Summary
Molybdenum cofactor (MoCo), YcbX and YiiM are involved in the detoxification of 6-N-hydroxylaminopurine (HAP), which proceeds by a reduction to adenine (Kozmin, 2008). [More information is available at EcoGene: EG13716]. YcbX functions in the molybdenum cofactor-dependent pathway for detoxification of N-hydroxylated base analogs . [More information is available at EcoCyc: G6487].
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Genomic context

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Sequence:
NC_000913.3 (1006491..1007600, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene dihydroorotate dehydrogenase, type 2 Neighboring gene cell division protein ZapC Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene ATP-binding protein Uup

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Zhai Y, et al. Protein Sci, 2002 Sep. PMID 12192075, Free PMC Article
  2. YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. Kozmin SG, et al. Mol Microbiol, 2008 Apr. PMID 18312271, Free PMC Article
  3. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043
  4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within toxin catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
6-N-hydroxylaminopurine resistance protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1006491..1007600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415467.1 6-N-hydroxylaminopurine resistance protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415467.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6L7CCJ6
    Conserved Domains (2) summary
    COG0633
    Location:288 → 367
    Fdx; Ferredoxin [Energy production and conversion]
    COG3217
    Location:1 → 271
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
Nucleotide Protein
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