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gstA glutathione S-transferase GstA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945758, updated on 17-Dec-2024

Summary

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Official Symbol
gstA
Official Full Name
glutathione S-transferase GstA
Primary source
ECOCYC:G6878
Locus tag
b1635
See related
ASAP:ABE-0005473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1631; gst
Summary
Glutathione S-transferase acts as a detoxifying enzyme. [More information is available at EcoCyc: G6878].
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Genomic context

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Sequence:
NC_000913.3 (1714377..1714982)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene SoxR [2Fe-2S] reducing system protein RsxE Neighboring gene endonuclease III Neighboring gene dipeptide/tripeptide:H(+) symporter DtpA Neighboring gene pyridoxal kinase 2 Neighboring gene tyrosine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys(10) and His(106). Wang XY, et al. Biochem J, 2009 Jan 1. PMID 18778244
  2. Chlorothalonil-biotransformation by glutathione S-transferase of Escherichia coli. Kim YM, et al. J Microbiol, 2004 Mar. PMID 15357291
  3. Molecular cloning and site-directed mutagenesis of glutathione S-transferase from Escherichia coli. The conserved tyrosyl residue near the N terminus is not essential for catalysis. Nishida M, et al. J Biol Chem, 1994 Dec 23. PMID 7798255
  4. Purification and some properties of glutathione S-transferase from Escherichia coli B. Iizuka M, et al. J Bacteriol, 1989 Nov. PMID 2553668, Free PMC Article
  5. Purification and study of a bacterial glutathione S-transferase. Arca P, et al. FEBS Lett, 1990 Apr 9. PMID 2185038

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Molecular cloning and site-directed mutagenesis of glutathione S-transferase from Escherichia coli. The conserved tyrosyl residue near the N terminus is not essential for catalysis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione S-transferase GstA
NP_416152.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1714377..1714982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416152.1 glutathione S-transferase GstA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416152.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7R3X4
    Conserved Domains (1) summary
    PRK10542
    Location:1 → 201
    PRK10542; glutathionine S-transferase; Provisional
Nucleotide Protein
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