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ribA GTP cyclohydrolase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945763, updated on 3-Dec-2024

Summary

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Official Symbol
ribA
Official Full Name
GTP cyclohydrolase 2
Primary source
ECOCYC:EG11331
Locus tag
b1277
See related
ASAP:ABE-0004285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1272
Summary
GTP cyclohydrolase II catalyzes the opening of the imidazole ring of GTP and removal of pyrophosphate, the first committed step in riboflavin biosynthesis. [More information is available at EcoCyc: EG11331].
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Genomic context

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Sequence:
NC_000913.3 (1338570..1339160, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YmiC Neighboring gene aconitate hydratase 1 Neighboring gene phosphatidylglycerophosphatase B Neighboring gene lipopolysaccharide assembly protein A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli. Foor F, et al. J Biol Chem, 1975 May 10. PMID 235552
  2. Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli. Richter G, et al. J Bacteriol, 1993 Jul. PMID 8320220, Free PMC Article
  3. Biosynthesis of vitamin B2. Kaiser J, et al. Eur J Biochem, 2002 Nov. PMID 12392559
  4. Biosynthesis of riboflavin. Single turnover kinetic analysis of GTP cyclohydrolase II. Schramek N, et al. J Biol Chem, 2001 Nov 23. PMID 11553632
  5. Regulation of the ribA gene encoding GTP cyclohydrolase II by the soxRS locus in Escherichia coli. Koh YS, et al. Mol Gen Genet, 1996 Jul 19. PMID 8709966

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP cyclohydrolase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP cyclohydrolase II activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP cyclohydrolase II activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in riboflavin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP cyclohydrolase 2
NP_415793.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1338570..1339160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415793.1 GTP cyclohydrolase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415793.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GIR8
    Conserved Domains (1) summary
    PRK00393
    Location:1 → 196
    ribA; GTP cyclohydrolase II RibA
Nucleotide Protein
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