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ychF redox-responsive ATPase YchF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945769, updated on 3-Dec-2024

Summary

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Official Symbol
ychF
Official Full Name
redox-responsive ATPase YchF
Primary source
ECOCYC:EG11404
Locus tag
b1203
See related
ASAP:ABE-0004038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1191; gtp1
Summary
ychF is in the pth operon; pth transcript stability depends on ychF integrity. otherPDB (H. influenzae): [More information is available at EcoGene: EG11404]. YchF is the founding member of a family of GTP-binding proteins . [More information is available at EcoCyc: EG11404].
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Genomic context

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Sequence:
NC_000913.3 (1256721..1257812, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator DhaR Neighboring gene putative autotransporter adhesin YcgV Neighboring gene peptidyl-tRNA hydrolase Neighboring gene stress-induced protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A universally conserved ATPase regulates the oxidative stress response in Escherichia coli. Wenk M, et al. J Biol Chem, 2012 Dec 21. PMID 23139412, Free PMC Article
  2. Deciphering the catalytic machinery in a universally conserved ribosome binding ATPase YchF. Tomar SK, et al. Biochem Biophys Res Commun, 2011 May 13. PMID 21527254
  3. Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. Brown ED. Biochem Cell Biol, 2005 Dec. PMID 16333325
  4. Transcriptional analysis of the gene encoding peptidyl-tRNA hydrolase in Escherichia coli. Cruz-Vera LR, et al. Microbiology (Reading), 2002 Nov. PMID 12427937
  5. Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis. García-Villegas MR, et al. EMBO J, 1991 Nov. PMID 1833189, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data provide novel insights into the regulation of the so far ill-defined YchF/Ola1 family of proteins and stipulate their role as negative regulators of the oxidative stress response
    Title: Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1.
  2. We have thereby identified the highly conserved His-114 as critical for the ATPase activity of YchF from Escherichia coli.
    Title: Histidine 114 Is Critical for ATP Hydrolysis by the Universally Conserved ATPase YchF.
  3. Escherichia coli YchF binds the 50S and 70S ribosomal particles in a nucleotide independent manner and it hydrolyzes ATP utilizing a potassium dependent mechanism.
    Title: Deciphering the catalytic machinery in a universally conserved ribosome binding ATPase YchF.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
redox-responsive ATPase YchF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1256721..1257812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415721.1 redox-responsive ATPase YchF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415721.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1NHD9, A0A376MWI2, A0A5B9AMW6
    Conserved Domains (1) summary
    PRK09601
    Location:1 → 363
    PRK09601; redox-regulated ATPase YchF
Nucleotide Protein
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