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cysB DNA-binding transcriptional dual regulator CysB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945771, updated on 17-Dec-2024

Summary

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Official Symbol
cysB
Official Full Name
DNA-binding transcriptional dual regulator CysB
Primary source
ECOCYC:EG10184
Locus tag
b1275
See related
ASAP:ABE-0004279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1269
Summary
LysR family. [More information is available at EcoGene: EG10184]. This protein controls the expression of the cysteine regulon (cysB, cysDNC, cysJIH, cysPUWAM, and cysK) that is a system of 10 or more loci involved in the biosynthesis of L-cysteine. [More information is available at EcoCyc: EG10184].
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Genomic context

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Sequence:
NC_000913.3 (1333855..1334829)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YciN Neighboring gene DNA topoisomerase 1 Neighboring gene uncharacterized protein YmiA Neighboring gene uncharacterized protein YciX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine. Verschueren KHG, et al. Eur Biophys J, 2024 Aug. PMID 38976018, Free PMC Article
  2. The molecular basis for positive regulation of cys promoters in Salmonella typhimurium and Escherichia coli. Kredich NM. Mol Microbiol, 1992 Oct. PMID 1435253
  3. Analysis of the Escherichia coli K-12 cysB gene and its product using the method of gene fusion. Tei H, et al. Biochem Biophys Res Commun, 1990 Mar 30. PMID 2182030
  4. In vitro interactions of CysB protein with the cysK and cysJIH promoter regions of Salmonella typhimurium. Monroe RS, et al. J Bacteriol, 1990 Dec. PMID 2254265, Free PMC Article
  5. Effect of DNA gyrase inhibitors and urea on the expression of cysB, the regulatory gene of the cysteine regulon. Bielińska A, et al. J Gen Microbiol, 1986 Sep. PMID 2432161

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
    Title: The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
  2. Upregulation of PBP1B and LpoB in cysB mutants confers mecillinam resistance in Escherichia coli.
    Title: Upregulation of PBP1B and LpoB in cysB Mutants Confers Mecillinam (Amdinocillin) Resistance in Escherichia coli.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Analysis of the Escherichia coli K-12 cysB gene and its product using the method of gene fusion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in cysteine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator CysB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1333855..1334829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415791.1 DNA-binding transcriptional dual regulator CysB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415791.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0B5HIE8, A0A0B5HL80, A0A828PKS6, A0A8S7RWM5
    Conserved Domains (1) summary
    PRK12681
    Location:1 → 324
    cysB; HTH-type transcriptional regulator CysB
Nucleotide Protein
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