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chaA Na(+)/K(+):H(+) antiporter ChaA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945790, updated on 3-Dec-2024

Summary

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Official Symbol
chaA
Official Full Name
Na(+)/K(+):H(+) antiporter ChaA
Primary source
ECOCYC:EG11753
Locus tag
b1216
See related
ASAP:ABE-0004082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1210
Summary
ChaA is a calcium ion: proton antiporter that is a member of the Calcium: [More information is available at EcoCyc: EG11753].
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Genomic context

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Sequence:
NC_000913.3 (1270749..1271849, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene small toxic polypeptide LdrC Neighboring gene ncRNA Neighboring gene putative cation transport regulator ChaB Neighboring gene glutathione-specific gamma-glutamylcyclotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. pH and monovalent cations regulate cytosolic free Ca(2+) in E. coli. Naseem R, et al. Biochim Biophys Acta, 2008 Jun. PMID 18342619
  2. Identification of three distinct phylogenetic groups of CAX cation/proton antiporters. Shigaki T, et al. J Mol Evol, 2006 Dec. PMID 17086450
  3. Fermenting Escherichia coli is able to grow in media of high osmolarity, but is sensitive to the presence of sodium ion. Trchounian A, et al. Curr Microbiol, 1999 Aug. PMID 10398838
  4. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. Ohyama T, et al. J Bacteriol, 1992 Dec. PMID 1332943, Free PMC Article
  5. Physiological role of the chaA gene in sodium and calcium circulations at a high pH in Escherichia coli. Ohyama T, et al. J Bacteriol, 1994 Jul. PMID 8021217, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to alkaline pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Na(+)/K(+):H(+) antiporter ChaA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1270749..1271849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415734.1 Na(+)/K(+):H(+) antiporter ChaA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415734.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WWN6
    Conserved Domains (1) summary
    PRK10599
    Location:1 → 366
    PRK10599; sodium-potassium/proton antiporter ChaA
Nucleotide Protein
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