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btuR cobinamide/cobalamin adenosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945839, updated on 3-Dec-2024

Summary

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Official Symbol
btuR
Official Full Name
cobinamide/cobalamin adenosyltransferase
Primary source
ECOCYC:EG10130
Locus tag
b1270
See related
ASAP:ABE-0004261
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cobA; ECK1264
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . [More information is available at EcoCyc: EG10130].
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Genomic context

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Sequence:
NC_000913.3 (1327767..1328357, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2207 domain-containing protein YciQ Neighboring gene 23S rRNA pseudouridine(2605) synthase Neighboring gene putative oxidoreductase Neighboring gene S49 peptidase family protein Neighboring gene protein YciN

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and overexpression of cobA which encodes ATP:corrinoid adenosyltransferase in Salmonella typhimurium. Suh SJ, et al. Gene, 1993 Jul 15. PMID 7916712
  2. Separate regulatory systems for the repression of metE and btuB by vitamin B12 in Escherichia coli. Lundrigan MD, et al. Mol Gen Genet, 1987 Mar. PMID 3108627
  3. cobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium. Escalante-Semerena JC, et al. J Bacteriol, 1990 Jan. PMID 2403541, Free PMC Article
  4. Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation. Lundrigan MD, et al. J Bacteriol, 1989 Jan. PMID 2644187, Free PMC Article
  5. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables corrinoid adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables corrinoid adenosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cobalamin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cobinamide/cobalamin adenosyltransferase
NP_415786.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1327767..1328357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415786.1 cobinamide/cobalamin adenosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415786.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QC73
    Conserved Domains (1) summary
    PRK05986
    Location:7 → 196
    PRK05986; cob(I)yrinic acid a,c-diamide adenosyltransferase
Nucleotide Protein
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