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trpL trp operon leader peptide [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945856, updated on 3-Dec-2024

Summary

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Official Symbol
trpL
Official Full Name
trp operon leader peptide
Primary source
ECOCYC:EG11274
Locus tag
b1265
See related
ASAP:ABE-0004246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1259; trpEE
Summary
The TrpL leader peptide is a key component in the attenuation system that controls expression of the trpLEDCBA operon in response to tryptophan availability . trpL occurs within a 130-nucleotide region at the beginning of the trp operon . [More information is available at EcoCyc: EG11274].
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Genomic context

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Sequence:
NC_000913.3 (1323038..1323082, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene anthranilate synthase subunit TrpD Neighboring gene anthranilate synthase subunit TrpE Neighboring gene RNase AM Neighboring gene putative RNA-binding protein YciO Neighboring gene DUF2207 domain-containing protein YciQ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Translational control of transcription termination at the attenuator of the Escherichia coli tryptophan operon. Zurawski G, et al. Proc Natl Acad Sci U S A, 1978 Dec. PMID 366606, Free PMC Article
  2. Single base-pair alterations in the Escherichia coli trp operon leader region that relieve transcription termination at the trp attenuator. Stauffer GV, et al. Proc Natl Acad Sci U S A, 1978 Oct. PMID 368800, Free PMC Article
  3. Transcription termination in vivo in the leader region of the tryptophan operon of Escherichia coli. Bertrand K, et al. J Mol Biol, 1976 May 15. PMID 781269
  4. Nucleotide sequence of the 5' end of tryptophan messenger RNA of Escherichia coli. Squires C, et al. J Mol Biol, 1976 May 15. PMID 781271
  5. Translation activates the paused transcription complex and restores transcription of the trp operon leader region. Landick R, et al. Proc Natl Acad Sci U S A, 1985 Jul. PMID 2991886, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of tryptophan metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tryptophan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
trp operon leader peptide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1323038..1323082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415781.1 trp operon leader peptide [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415781.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AD92
Nucleotide Protein
Heading Accession and Version

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