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ftsB cell division protein FtsB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946033, updated on 3-Dec-2024

Summary

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Official Symbol
ftsB
Official Full Name
cell division protein FtsB
Primary source
ECOCYC:G7424
Locus tag
b2748
See related
ASAP:ABE-0009019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2743; ygbQ
Summary
ftsB is an essential gene. [More information is available at EcoGene: EG13111]. FtsB is an essential cell division protein which localizes to the cell division site. [More information is available at EcoCyc: G7424].
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Genomic context

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Sequence:
NC_000913.3 (2872509..2872820, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Neighboring gene DUF3561 domain-containing inner membrane protein YgbE Neighboring gene adenylyl-sulfate kinase Neighboring gene sulfate adenylyltransferase subunit 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural organization of FtsB, a transmembrane protein of the bacterial divisome. LaPointe LM, et al. Biochemistry, 2013 Apr 16. PMID 23520975, Free PMC Article
  2. Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB. Kureisaite-Ciziene D, et al. mBio, 2018 Sep 11. PMID 30206170, Free PMC Article
  3. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions. Condon SGF, et al. J Biol Chem, 2018 Feb 2. PMID 29233891, Free PMC Article
  4. Bacterial cytokinesis: From Z ring to divisome. Lutkenhaus J, et al. Cytoskeleton (Hoboken), 2012 Oct. PMID 22888013, Free PMC Article
  5. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation. Kong WP, et al. J Biol Chem, 2022 Aug. PMID 35798142, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
  2. The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB.
    Title: Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.
  3. Crystal structure of FtsB bound to the beta domain of FtsQ shows that only residues 64 to 87 of FtsB interact with FtsQ.
    Title: Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.
  4. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
    Title: The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
  5. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
    Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
  6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
    Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
  7. The authors demonstrate that the leucine zipper-like (LZ) motifs, located in the periplasmic domain of FtsL and FtsB, are required for an optimal interaction between these two essential proteins.
    Title: Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB.
  8. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
    Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
  9. The N-terminal half of FtsB is necessary for interaction with FtsL and sufficient, when in complex with FtsL, for recruitment of downstream division proteins, while a portion of the FtsB C terminus is necessary for interaction with FtsQ.
    Title: Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins.
  10. FtsB is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
    Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of FtsBL complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of FtsQBL complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell division site IEA
Inferred from Electronic Annotation
more info
  
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cell septum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell septum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of divisome complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cell division protein FtsB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2872509..2872820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417228.1 cell division protein FtsB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417228.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TUJ3
    Conserved Domains (1) summary
    PRK00888
    Location:16 → 103
    ftsB; cell division protein FtsB; Reviewed
Nucleotide Protein
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