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tmcA tRNA(Met) cytidine acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946053, updated on 3-Dec-2024

Summary

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Official Symbol
tmcA
Official Full Name
tRNA(Met) cytidine acetyltransferase
Primary source
ECOCYC:G7297
Locus tag
b2474
See related
ASAP:ABE-0008150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2470; ypfI
Summary
tRNAMet cytidine acetyltransferase acetylates the wobble base C34 of the elongation-specific tRNAMet. [More information is available at EcoCyc: G7297].
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Genomic context

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Sequence:
NC_000913.3 (2593844..2595859, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF13980 family protein YpfN Neighboring gene esterase YpfH Neighboring gene uncharacterized protein YpfJ Neighboring gene phosphoribosylaminoimidazole-succinocarboxamide synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription. Dong H, et al. Nat Chem Biol, 2022 Feb. PMID 34903851
  2. The role of the minor base N4-acetylcytidine in the function of the Escherichia coli noninitiator methionine transfer RNA. Stern L, et al. J Biol Chem, 1978 Sep 10. PMID 355249
  3. The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. Ikeuchi Y, et al. EMBO J, 2008 Aug 20. PMID 18668122, Free PMC Article
  4. Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. Yamamoto Y, et al. DNA Res, 1997 Apr 28. PMID 9205837
  5. RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon. Chimnaronk S, et al. EMBO J, 2009 May 6. PMID 19322199, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide 2-hydroxyisobutyryltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA cytidine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble cytosine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble cytosine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble cytosine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA(Met) cytidine acetyltransferase
NP_416969.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2593844..2595859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416969.1 tRNA(Met) cytidine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416969.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QTU7
    Conserved Domains (1) summary
    COG1444
    Location:1 → 671
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version

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