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ydfG 3-hydroxy acid dehydrogenase YdfG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946085, updated on 3-Dec-2024

Summary

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Official Symbol
ydfG
Official Full Name
3-hydroxy acid dehydrogenase YdfG
Primary source
ECOCYC:EG12345
Locus tag
b1539
See related
ASAP:ABE-0005137
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1532
Summary
The product of the oxidation of the 3-hydroxyl group of L-allo-threonine is aminoacetone, via spontaneous decarboxylation of the primary reaction product L-2-amino-3-ketobutyrate. [More information is available at EcoGene: EG12345]. The ydfG gene encodes a homotetrameric NADP(+)-dependent 3-hydroxy acid dehydrogenase . [More information is available at EcoCyc: EG12345].
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Genomic context

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Sequence:
NC_000913.3 (1627517..1628263)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF02464 family protein YdeJ Neighboring gene peptidyl-dipeptidase Dcp Neighboring gene DNA-binding transcriptional repressor RspR Neighboring gene putative selenoprotein YdfZ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C). Fujisawa H, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535615
  2. dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product. Henrich B, et al. J Bacteriol, 1993 Nov. PMID 8226676, Free PMC Article
  3. Proteomic analysis of beryllium-induced genotoxicity in an Escherichia coli mutant model system. Taylor-McCabe KJ, et al. Proteomics, 2006 Mar. PMID 16447159
  4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
  5. Intrinsic and extrinsic approaches for detecting genes in a bacterial genome. Borodovsky M, et al. Nucleic Acids Res, 1994 Nov 11. PMID 7984428, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxypropionate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxypropionate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine 3-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxy acid dehydrogenase YdfG
NP_416057.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1627517..1628263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416057.1 3-hydroxy acid dehydrogenase YdfG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416057.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R1P1, A0A8S7TGA8
    Conserved Domains (1) summary
    PRK10538
    Location:1 → 248
    PRK10538; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG
Nucleotide Protein
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