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poxB pyruvate oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946132, updated on 3-Dec-2024

Summary

Official Symbol
poxB
Official Full Name
pyruvate oxidase
Primary source
ECOCYC:EG10754
Locus tag
b0871
See related
ASAP:ABE-0002958
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0862
Summary
Metabolism of pyruvate via pyruvate oxidase is less efficient than the route via the pyruvate dehydrogenase multienzyme complex; however, the pyruvate oxidase route is important for wild-type growth efficiency and responsible for a significant amount of pyruvate metabolism under aerobic conditions . [More information is available at EcoCyc: EG10754].
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Genomic context

Sequence:
NC_000913.3 (909331..911049, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative NAD(P)-binding protein YbjT Neighboring gene low-specificity L-threonine aldolase Neighboring gene NADH oxidoreductase Neighboring gene protein S-nitrosylase

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding PubMed 
enables flavin adenine dinucleotide binding  
enables identical protein binding PubMed 
enables identical protein binding PubMed 
enables lipid binding PubMed 
enables lipid binding  
enables magnesium ion binding PubMed 
enables magnesium ion binding  
enables metal ion binding  
enables nucleotide binding  
enables oxidoreductase activity  
enables pyruvate dehydrogenase (quinone) activity PubMed 
enables pyruvate dehydrogenase (quinone) activity  
enables thiamine pyrophosphate binding PubMed 
enables thiamine pyrophosphate binding  
enables ubiquinone binding  
Component Evidence Code Pubs
located_in cytosol PubMed 
located_in cytosol PubMed 
located_in plasma membrane  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
pyruvate oxidase
NP_415392.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    909331..911049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415392.1 pyruvate oxidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415392.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FNI8, A0A377AVX4
    Conserved Domains (1) summary
    PRK09124
    Location:1 → 572
    PRK09124; ubiquinone-dependent pyruvate dehydrogenase
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