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mdtJ multidrug/spermidine efflux pump membrane subunit MdtJ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946139, updated on 3-Dec-2024

Summary

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Official Symbol
mdtJ
Official Full Name
multidrug/spermidine efflux pump membrane subunit MdtJ
Primary source
ECOCYC:G6858
Locus tag
b1600
See related
ASAP:ABE-0005345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1595; ydgF
Summary
MdtJ belongs to the SMR efflux pump family, DMT superfamily. [More information is available at EcoGene: EG13927]. MdtJ is part of the MdtJI spermidine SMR transporter. [More information is available at EcoCyc: G6858].
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Genomic context

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Sequence:
NC_000913.3 (1673136..1673501, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YdgU Neighboring gene putative serine protease YdgD Neighboring gene multidrug/spermidine efflux pump membrane subunit MdtI Neighboring gene protein MdtU Neighboring gene autoinducer 2 exporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of novel multidrug transporters from human pathogens. Ninio S, et al. J Biol Chem, 2001 Dec 21. PMID 11574548
  2. Small multidrug resistance proteins: a multidrug transporter family that continues to grow. Bay DC, et al. Biochim Biophys Acta, 2008 Sep. PMID 17942072
  3. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Paulsen IT, et al. Mol Microbiol, 1996 Mar. PMID 8730859
  4. N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2006 Aug. PMID 16885453, Free PMC Article
  5. EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli. Nishino K, et al. J Bacteriol, 2002 Apr. PMID 11914367, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amino-acid betaine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in choline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermidine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermidine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of transmembrane transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
multidrug/spermidine efflux pump membrane subunit MdtJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1673136..1673501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416117.1 multidrug/spermidine efflux pump membrane subunit MdtJ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416117.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJQ0
    Conserved Domains (1) summary
    PRK10452
    Location:2 → 121
    PRK10452; multidrug/spermidine efflux SMR transporter subunit MdtJ
Nucleotide Protein
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