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leuE leucine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946157, updated on 3-Dec-2024

Summary

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Official Symbol
leuE
Official Full Name
leucine exporter
Primary source
ECOCYC:G6984
Locus tag
b1798
See related
ASAP:ABE-0005984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1796; yeaS
Summary
Lrp regulon, leucine-induced. [More information is available at EcoGene: EG13505]. The yeaS gene encodes the leucine exporter LeuE. [More information is available at EcoCyc: G6984].
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Genomic context

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Sequence:
NC_000913.3 (1880121..1880759, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1869 domain-containing protein YoaG Neighboring gene DUF1971 domain-containing protein YeaR Neighboring gene DNA-binding transcriptional regulator DmlR Neighboring gene D-malate/3-isopropylmalate dehydrogenase (decarboxylating)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression. Kutukova EA, et al. FEBS Lett, 2005 Aug 29. PMID 16098526
  2. [Expression of the genes encoding RhtB family proteins depends on global regulator Lrp]. Kutukova EA, et al. Mol Biol (Mosk), 2005 May-Jun. PMID 15981566
  3. Cell-free complements in vivo expression of the E. coli membrane proteome. Savage DF, et al. Protein Sci, 2007 May. PMID 17456747, Free PMC Article
  4. New ubiquitous translocators: amino acid export by Corynebacterium glutamicum and Escherichia coli. Eggeling L, et al. Arch Microbiol, 2003 Sep. PMID 12879215
  5. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that yeaS encodes an exporter of leucine and that its expression is regulated by Lrp.
    Title: The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-leucine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-leucine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-leucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-leucine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1880121..1880759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416312.1 leucine exporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416312.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376Y8H9
    Conserved Domains (1) summary
    PRK10958
    Location:1 → 212
    PRK10958; leucine export protein LeuE; Provisional
Nucleotide Protein
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