U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gloA lactoylglutathione lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946161, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
gloA
Official Full Name
lactoylglutathione lyase
Primary source
ECOCYC:G6891
Locus tag
b1651
See related
ASAP:ABE-0005520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1647
Summary
Glyoxalase I catalyzes the first of two sequential steps in the conversion of methylgloxal to D-lactate. [More information is available at EcoCyc: G6891].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1727837..1728244)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor NemR Neighboring gene N-ethylmaleimide reductase Neighboring gene ribonuclease T Neighboring gene ATP-dependent helicase Lhr

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An XAS investigation of product and inhibitor complexes of Ni-containing GlxI from Escherichia coli: mechanistic implications. Davidson G, et al. Biochemistry, 2001 Apr 17. PMID 11294624
  2. Growth inhibitory properties of aromatic alpha-ketoaldehydes toward bacteria and yeast. Comparison of inhibition and glyoxalase I activity. Vander Jagt DL. J Med Chem, 1975 Nov. PMID 1100829
  3. Isolation and sequencing of a gene coding for glyoxalase I activity from Salmonella typhimurium and comparison with other glyoxalase I sequences. Clugston SL, et al. Gene, 1997 Feb 20. PMID 9047352
  4. Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions. Clugston SL, et al. Biochemistry, 1998 Jun 16. PMID 9628737
  5. Structure/function relationships in nickel metallobiochemistry. Maroney MJ. Curr Opin Chem Biol, 1999 Apr. PMID 10226043

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glyoxalase I alone among the core methylglyoxal protective systems is induced in response to methylglyoxal exposure.
    Title: Integrated stress response of Escherichia coli to methylglyoxal: transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I.
  2. We propose that cells have a cytosolic system consisting of the nemRA-gloA operon for the reduction of electrophiles, especially quinones and glyoxals, to maintain an appropriate intracellular redox balance.
    Title: Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lactoylglutathione lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactoylglutathione lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lactoylglutathione lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
lactoylglutathione lyase
NP_416168.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1727837..1728244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416168.1 lactoylglutathione lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416168.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5H119, A0A3P5DQY7
    Conserved Domains (1) summary
    TIGR00068
    Location:2 → 135
    glyox_I; lactoylglutathione lyase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.