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sppA protease IV, a signal peptide peptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946281, updated on 17-Dec-2024

Summary

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Official Symbol
sppA
Official Full Name
protease IV, a signal peptide peptidase
Primary source
ECOCYC:EG10968
Locus tag
b1766
See related
ASAP:ABE-0005880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1764
Summary
Protease IV is an endopeptidase that degrades cleaved signal peptide . [More information is available at EcoCyc: EG10968].
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Genomic context

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Sequence:
NC_000913.3 (1848837..1850693)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene selenide, water dikinase Neighboring gene putative oxidoreductase YdjA Neighboring gene L-asparaginase 1 Neighboring gene nicotinamidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Minimum substrate sequence for signal peptidase I of Escherichia coli. Dev IK, et al. J Biol Chem, 1990 Nov 25. PMID 2243078
  2. Mutational evidence of transition state stabilization by serine 88 in Escherichia coli type I signal peptidase. Carlos JL, et al. Biochemistry, 2000 Jun 20. PMID 10852727
  3. Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. Wang P, et al. Biochemistry, 2008 Jun 17. PMID 18476724, Free PMC Article
  4. Degradation of a signal peptide by protease IV and oligopeptidase A. Novak P, et al. J Bacteriol, 1988 Nov. PMID 3053642, Free PMC Article
  5. Localization and purification of two enzymes from Escherichia coli capable of hydrolyzing a signal peptide. Novak P, et al. J Biol Chem, 1986 Jan 5. PMID 3510201

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal peptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protease IV, a signal peptide peptidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1848837..1850693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416280.1 protease IV, a signal peptide peptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416280.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8N9T4
    Conserved Domains (1) summary
    PRK10949
    Location:1 → 618
    PRK10949; signal peptide peptidase SppA
Nucleotide Protein
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