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fadD long-chain-fatty-acid--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946327, updated on 17-Dec-2024

Summary

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Official Symbol
fadD
Official Full Name
long-chain-fatty-acid--CoA ligase
Primary source
ECOCYC:EG11530
Locus tag
b1805
See related
ASAP:ABE-0006005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1803; oldD
Summary
The FadD protein, encoding fatty acyl-CoA synthetase, can transport long chain fatty acids across the inner membrane in an in vitro system . [More information is available at EcoCyc: EG11530].
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Genomic context

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Sequence:
NC_000913.3 (1888061..1889746, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene carnitine monooxygenase subunit YeaX Neighboring gene RNase D Neighboring gene Slp family lipoprotein YeaY Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase. Black PN, et al. J Biol Chem, 1992 Dec 15. PMID 1460045
  2. Partial purification and properties of acyl-CoA synthetase of Escherichia coli. Samuel D, et al. Eur J Biochem, 1970 Feb. PMID 4909455
  3. Bacterial long chain fatty acid transport: gateway to a fatty acid-responsive signaling system. Dirusso CC, et al. J Biol Chem, 2004 Nov 26. PMID 15347640
  4. Biochemical demonstration of the involvement of fatty acyl-CoA synthetase in fatty acid translocation across the plasma membrane. Schmelter T, et al. J Biol Chem, 2004 Jun 4. PMID 15067008
  5. Purification and characterization of acyl coenzyme A synthetase from Escherichia coli. Kameda K, et al. J Biol Chem, 1981 Jun 10. PMID 7016858

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
    Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity, forming carbon-sulfur bonds IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oleic acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase
NP_416319.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1888061..1889746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416319.1 long-chain-fatty-acid--CoA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416319.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7ELC5
    Conserved Domains (1) summary
    PRK08974
    Location:1 → 560
    PRK08974; long-chain-fatty-acid--CoA ligase FadD
Nucleotide Protein
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