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sdaA L-serine deaminase I [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946331, updated on 3-Dec-2024

Summary

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Official Symbol
sdaA
Official Full Name
L-serine deaminase I
Primary source
ECOCYC:EG10930
Locus tag
b1814
See related
ASAP:ABE-0006039
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1812
Summary
L-serine deaminase I (SdaA) is one of three enzymes carrying out the sole step in the pathway of L-serine degradation, converting serine into a basic cellular building block, pyruvate. [More information is available at EcoCyc: EG10930].
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Genomic context

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Sequence:
NC_000913.3 (1896932..1898296)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate synthase subunit 1 Neighboring gene putative NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity Neighboring gene putative c-di-GMP phosphodiesterase PdeD Neighboring gene TerC family inner membrane protein YoaE Neighboring gene protein YoaL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro and in vivo activation of L-serine deaminase in Escherichia coli K-12. Newman EB, et al. J Bacteriol, 1985 Jun. PMID 3888962, Free PMC Article
  2. In vitro studies on L-serine deaminase activity of Escherichia coli K12. Newman EB, et al. Can J Biochem, 1980 Nov. PMID 7011505
  3. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli. Wiebe MA, et al. mBio, 2022 Dec 20. PMID 36468870, Free PMC Article
  4. Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis. Cicchillo RM, et al. J Biol Chem, 2004 Jul 30. PMID 15155761
  5. Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Zhang X, et al. Mol Microbiol, 2008 Aug. PMID 18532981

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
    Title: Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Use of gene fusions of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-serine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
L-serine deaminase I
NP_416328.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1896932..1898296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416328.1 L-serine deaminase I [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416328.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJJ6, A0A7A6VR80
    Conserved Domains (1) summary
    PRK15023
    Location:1 → 454
    PRK15023; L-serine deaminase; Provisional
Nucleotide Protein
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