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pabB aminodeoxychorismate synthase subunit 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946337, updated on 3-Dec-2024

Summary

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Official Symbol
pabB
Official Full Name
aminodeoxychorismate synthase subunit 1
Primary source
ECOCYC:EG10683
Locus tag
b1812
See related
ASAP:ABE-0006031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1810
Summary
Component I catalyzes the formation of ADC by binding chorismate and ammonia. [More information is available at EcoCyc: EG10683].
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Genomic context

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Sequence:
NC_000913.3 (1894805..1896166)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1889 domain-containing protein YoaC Neighboring gene UFP0181 family protein YoaH Neighboring gene putative NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity Neighboring gene L-serine deaminase I

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes. Parsons JF, et al. Biochemistry, 2002 Feb 19. PMID 11841211
  2. p-Aminobenzoate synthesis in Escherichia coli: mutational analysis of three conserved amino acid residues of the amidotransferase PabA. Roux B, et al. Biochemistry, 1993 Apr 13. PMID 8096767
  3. p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. Roux B, et al. Biochemistry, 1992 Aug 4. PMID 1637823
  4. Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase. Walsh CT, et al. Biochemistry, 1987 Jul 28. PMID 3311153
  5. Genetic analysis of mutant strains of Escherichia coli requiring p-aminobenzoic acid for growth. Huang M, et al. J Bacteriol, 1967 Jun. PMID 5337773, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-amino-4-deoxychorismate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-amino-4-deoxychorismate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-amino-4-deoxychorismate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in folic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in folic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of aminodeoxychorismate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminodeoxychorismate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
aminodeoxychorismate synthase subunit 1
NP_416326.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1894805..1896166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416326.1 aminodeoxychorismate synthase subunit 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416326.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BHI9
    Conserved Domains (1) summary
    PRK15465
    Location:1 → 453
    pabB; aminodeoxychorismate synthase component 1
Nucleotide Protein
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