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znuA Zn(2(+)) ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946375, updated on 3-Dec-2024

Summary

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Official Symbol
znuA
Official Full Name
Zn(2(+)) ABC transporter periplasmic binding protein
Primary source
ECOCYC:G7017
Locus tag
b1857
See related
ASAP:ABE-0006191
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1858; yebL; yzzP
Summary
[More information is available at EcoCyc: G7017].
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Genomic context

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Sequence:
NC_000913.3 (1941651..1942583, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Lipid A biosynthesis myristoyltransferase Neighboring gene peptidoglycan endopeptidase MepM Neighboring gene Zn(2(+)) ABC transporter ATP binding subunit Neighboring gene Zn(2(+)) ABC transporter membrane subunit Neighboring gene Holliday junction branch migration complex subunit RuvB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. Yatsunyk LA, et al. J Biol Inorg Chem, 2008 Feb. PMID 18027003, Free PMC Article
  2. Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination. Li H, et al. J Mol Biol, 2007 May 18. PMID 17399739
  3. Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release. Chandra BR, et al. J Mol Biol, 2007 Apr 6. PMID 17306297, Free PMC Article
  4. Periplasmic competition for zinc uptake between the metallochaperone ZnuA and Cu,Zn superoxide dismutase. Berducci G, et al. FEBS Lett, 2004 Jul 2. PMID 15225650
  5. Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins. Graham AI, et al. J Biol Chem, 2009 Jul 3. PMID 19377097, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structures of E. coli ZnuA (Eco-ZnuA) in the apo, Zn(2+)-bound, and Co(2+)-bound forms have been determined.
    Title: Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
  3. Crystal structure of the high-affinity zinc transporter ZnuA from Escherichia coli at 1.8 A resolution.
    Title: Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release.
  4. Data show that the crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination.
    Title: Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within zinc ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Zn(2(+)) ABC transporter periplasmic binding protein
NP_416371.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1941651..1942583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416371.4 Zn(2(+)) ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416371.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R216, A0A7T2J4Z6
    Conserved Domains (1) summary
    PRK09545
    Location:2 → 308
    znuA; zinc ABC transporter substrate-binding protein ZnuA
Nucleotide Protein
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